Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add filters








Language
Year range
1.
Biocell ; 28(1): 31-34, Apr. 2004.
Article in English | LILACS | ID: lil-384230

ABSTRACT

In previous work the bacteriostatic action of trihydroxylated chalcones against Staphylococcus aureus ATCC 25 923 was investigated. In this work the action of 2',4',2-(OH)3-chalcone, 2',4',3-(OH)3-chalcone and 2',4',4-(OH)3-chalcone against Escherichia coli ATCC 25 922 was evaluated. Growth kinetic curves of E. coli were made in nutritive broth added with increasing drug concentrations. The specific growth rates of the microorganisms were calculated by a kinetic turbidimetric method, which was previously probed and the minimal inhibitory concentrations (MIC's) were evaluated by a mechanism of action proposed. The MICs of 2',4',3-(OH)3-chalcone and 2',4',2-(OH)3-chalcone were 46 microg/ml and 122 microg/ml, respectively. The 2',4',4-(OH)3-chalcone was inactive. The MIC value of 2',4',3-(OH)3-chalcone (46 microg/ml), more active than 2',3-(OH)2-chalcone (72.2 microg/ml) may be due to the introduction of an electron donating group (-OH) at position 4' in the aromatic A-ring, which activates the region that includes the 2'-hydroxyl neighbor group and the alpha,beta-unsaturated carbonyl group.


Subject(s)
Anti-Bacterial Agents/pharmacology , Chalcone/analogs & derivatives , Chalcone/pharmacology , Escherichia coli/drug effects , Hydroxyl Radical/chemistry , Colony Count, Microbial , Chalcone/chemistry , Dose-Response Relationship, Drug , Cell Division/drug effects , Cell Division/physiology , Escherichia coli/growth & development , Microbial Sensitivity Tests , Structure-Activity Relationship
SELECTION OF CITATIONS
SEARCH DETAIL